The game seems to perform better on the PC and Wii than on the other versions.

The visuals of the PC version can be boosted further with the help of 3rd-party software, such as Nvidia Inspector, which can add modern enhancements, like HBAO+ and SGSSAA.

The PC version of Manhunt 2 has much better visuals than the other versions, The Wii version also is visually superior to the Beta, PS2, and PSP, although it's not as good as on the PC.

There is a bonus tutorial in the Wii and PC that lets players become used to the controls.

In the Beta, PS2, and PSP versions, the player must press a button combination until the hunter leaves in the Wii version the player must keep the Wii remote/ nunchuck still and in the PC version, a circle with a dot in the middle appears on screen and players must use the mouse to keep the dot in the circle(which begin to get smaller and move around) until the circle turns green and the hunter gives up.

The sequence of regulating your breathing when a hunter is investigating your shadow is different in some versions.

There is no quick turn feature in the Wii and PC versions of the game.

On the PC, you can also take off interactive executions in the options menu, so the game can be played without motion gestures.

The Wii and PC feature motion controlled actions, such as performing and carrying out an execution.

The font in the PC and Wii versions of is larger and different than in other versions.

There is some hunter dialogue in the Wii and PC versions of the game that does not appear in the other versions.

The music score in the PC and Wii versions of Manhunt 2 is noticeably easier to hear than in the PSP, PS2, and Beta versions.

The Wii controller has a speaker on it which Rockstar used to play some audio through.

The PS2 version of the game is the only one that supports a headset.

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